Neural mechanisms of addiction / [edited by] Mary Torregrossa.

Includes bibliographical references and index.

Introduction to the neural basis of addiction -- Animal models of addiction -- Transcriptional and epigenetic regulation and reward circuitry in drug addiction -- Neural circuit plasticity in addiction -- Glutamatergic neuroplasticity in addiction -- Fos-expressing neuronal ensembles in addiction research -- Interoceptive stimulus effects of drugs of abuse -- Maladaptive memory mechanisms in addiction and relapse -- Neural morphology and addiction -- Mechanisms regulating compulsive drug behaviors -- Role of stress-associated signaling in addiction -- Negative reinforcement mechanisms in addiction -- Circadian rhythms and addiction -- Role of Oxytocin in countering addiction-associated behaviors exacerbated by stress -- The role of norepinephrine in drug addiction: past, present, and future -- Glial disregulation in addiction -- Role of the extracellular matrix in addiction -- Striatal cell-tyle specific plasticity in addiction -- Harnessing circuits for the treatment of addictive disorders -- Conclusions and future directions.

Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research.